Good Cosmetic Ingredient NOAEL Data

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate

INCI: DIGLYCERYL ADIPATE/CAPRATE/CAPRYLATE/HYDROXYSTEARATE/ISOSTEARATE/STEARATE

CAS Number
130905-60-1
Function
Emollient, skin conditioning agent (complex mixed diglyceryl ester)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not listed in 21 CFR 700; CIR reviewed glyceryl monoesters as a class and found them safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1800 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1800 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH

Expert Verdict

Multi-component ester with potential batch-to-batch variability in ester composition; confirm supplier specifications match INCI definition; CIR class review supports safety but does not specifically cover this INCI.

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Concern Level: Low

Frequently Asked Questions

Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate safe in cosmetics?

Multi-component ester with potential batch-to-batch variability in ester composition; confirm supplier specifications match INCI definition; CIR class review supports safety but does not specifically cover this INCI. The EU classifies Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.

Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate allowed in the EU?

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate do in cosmetics?

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate functions as: Emollient, skin conditioning agent (complex mixed diglyceryl ester). It is classified as a cosmetic ingredient in our database. CAS number: 130905-60-1.

What is the Margin of Safety for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate?

The NOAEL (No Observed Adverse Effect Level) for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate is 1800 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

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