Good Cosmetic Ingredient NOAEL Data

Dilauryl Thiodipropionate

INCI: DILAURYL THIODIPROPIONATE

CAS Number
123-28-4
Function
Antioxidant, Sequestering Agent, Fragrance
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS as food substance under 21 CFR 182.3109 (total antioxidant content โ‰ค0.02% of fat/oil content). CIR (2010 amended assessment) deemed safe for use in cosmetics formulated to be non-irritating.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Dilauryl Thiodipropionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 350 mg/kg bw/day oral rat oral REACH
NOEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOEL >5000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Non-phenolic antioxidant with strong safety record; GRAS status for food use and CIR-safe for cosmetics with well-characterized negative genotoxicity profile and low acute toxicity.

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Concern Level: Low

Regulatory Flags

cir-safe gras-fda no-sccs-opinion non-genotoxic oil-soluble-only non-irritating-as-formulated ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Dilauryl Thiodipropionate safe in cosmetics?

Non-phenolic antioxidant with strong safety record; GRAS status for food use and CIR-safe for cosmetics with well-characterized negative genotoxicity profile and low acute toxicity. The EU classifies Dilauryl Thiodipropionate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Dilauryl Thiodipropionate allowed in the EU?

Dilauryl Thiodipropionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dilauryl Thiodipropionate do in cosmetics?

Dilauryl Thiodipropionate functions as: Antioxidant, Sequestering Agent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 123-28-4.

What is the Margin of Safety for Dilauryl Thiodipropionate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dilauryl Thiodipropionate?

The NOAEL (No Observed Adverse Effect Level) for Dilauryl Thiodipropionate is 350 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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