Is 2,5-DIMETHYLPYRAZINE safe in cosmetics?
2,5-DIMETHYLPYRAZINE has a safety rating of "GOOD" in our database. EU status: permitted.
GOOD
Cosmetic Ingredient
2,5-DIMETHYLPYRAZINE
Also known as: 2,5-Dimethyl-1,4-diazine, 2,5-Dimethylparadiazine, 2,5-Dimethylpiazine, EINECS 204-618-3, FEMA No. 3272 (+6 more)
2,5-DIMETHYLPYRAZINE (CAS 123-32-0) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Perfuming
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2,5-dimethylpyrazine
InChIKey
LCZUOKDVTBMCMX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
766
Source: WHO/JECFA
JECFA Evaluation
2,5-DIMETHYL-1,4-DIAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
JECFA Evaluation
KETINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
JECFA Evaluation
2,5-DIMETHYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for 2,5-DIMETHYLPYRAZINE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2,5-Dimethyl-1,4-diazine
2,5-Dimethylparadiazine
2,5-Dimethylpiazine
EINECS 204-618-3
FEMA No. 3272
UNII-V99Y0MUY1Q
2, 5-Dimethylpyrazine
2,5-Dimethyl pyrazine
2,5-Dimethyl-Pyrazine
FEMA 3272
PYRAZINE,2,5-DIMETHYL
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL94709
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2,5-DIMETHYLPYRAZINE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2,5-DIMETHYLPYRAZINE allowed in the EU?
2,5-DIMETHYLPYRAZINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,5-DIMETHYLPYRAZINE do in cosmetics?
2,5-DIMETHYLPYRAZINE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 123-32-0.
Is 2,5-DIMETHYLPYRAZINE used outside cosmetics?
2,5-DIMETHYLPYRAZINE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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