Good Cosmetic Ingredient NOAEL Data GHS Classified

2-Octanol

INCI: 2-OCTANOL

CAS Number
123-96-6
Function
Fragrance ingredient, solvent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Safety Rating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2-Octanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

Standard secondary fatty alcohol with minimal irritation at cosmetic-use levels.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 2-Octanol safe in cosmetics?

Standard secondary fatty alcohol with minimal irritation at cosmetic-use levels. The EU classifies 2-Octanol as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 2-Octanol allowed in the EU?

2-Octanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Octanol do in cosmetics?

2-Octanol functions as: Fragrance ingredient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 123-96-6.

What is the Margin of Safety for 2-Octanol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Octanol?

The NOAEL (No Observed Adverse Effect Level) for 2-Octanol is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

Compliance Tools

Check 2-Octanol compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

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Good
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