Dimethiconol Isostearate

INCI: DIMETHICONOL ISOSTEARATE

CAS Number
133448-14-3
Function
Skin-conditioning agent — occlusive
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not prohibited or restricted under 21 CFR; isostearic acid CIR-reviewed safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Well-characterized ester with defined CAS number. Isostearic acid moiety CIR-safe. Compatible with diverse emulsifier systems.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Dimethiconol Isostearate safe in cosmetics?

Well-characterized ester with defined CAS number. Isostearic acid moiety CIR-safe. Compatible with diverse emulsifier systems. The EU classifies Dimethiconol Isostearate as "permitted". Safety rating: EXCELLENT.

Is Dimethiconol Isostearate allowed in the EU?

Dimethiconol Isostearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethiconol Isostearate do in cosmetics?

Dimethiconol Isostearate functions as: Skin-conditioning agent — occlusive. It is classified as a cosmetic ingredient in our database. CAS number: 133448-14-3.

What is the Margin of Safety for Dimethiconol Isostearate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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