Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Confirm exact isomer and CAS before CPSR submission. No CIR or SCCS opinion available. Flavonoid class is generally GRAS for oral use, but topical toxicology data are sparse. Requires supplier Certificate of Analysis and supporting in vitro safety data.
Frequently Asked Questions
Is Dimethoxyapigenin safe in cosmetics?
Confirm exact isomer and CAS before CPSR submission. No CIR or SCCS opinion available. Flavonoid class is generally GRAS for oral use, but topical toxicology data are sparse. Requires supplier Certificate of Analysis and supporting in vitro safety data. The EU classifies Dimethoxyapigenin as "permitted". Safety rating: MODERATE.
Is Dimethoxyapigenin allowed in the EU?
Dimethoxyapigenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethoxyapigenin do in cosmetics?
Dimethoxyapigenin functions as: Antioxidant, Skin Conditioning (flavone derivative of apigenin CAS 520-36-5). It is classified as a cosmetic ingredient in our database. CAS number: Verify — multiple dimethoxy isomers exist (e.g., acacetin CAS 480-44-4 for 4′,5-dihydroxy-7-methoxyflavone; other isomers differ).
What is the Margin of Safety for Dimethoxyapigenin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Dimethoxyapigenin compliance across multiple jurisdictions:
Related Ingredients
Is Dimethoxyapigenin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dimethoxyapigenin in your formulation.