Dimethoxydiglycol

INCI: DIMETHOXYDIGLYCOL

CAS Number
111-96-6 (bis(2-methoxyethyl) ether / diglyme)
Function
Solvent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically prohibited by FDA CFR, but classified as a reproductive toxicant. CIR has not issued a safe-use opinion.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Do not use in EU-market products. Reproductive and developmental toxicant. Structurally related to ethoxydiglycol which is itself restricted. For US-market products, inclusion would fail responsible safety assessment due to reproductive toxicity classification.

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Concern Level: High

Frequently Asked Questions

Is Dimethoxydiglycol safe in cosmetics?

Do not use in EU-market products. Reproductive and developmental toxicant. Structurally related to ethoxydiglycol which is itself restricted. For US-market products, inclusion would fail responsible safety assessment due to reproductive toxicity classification. The EU classifies Dimethoxydiglycol as "prohibited". Safety rating: POOR.

Is Dimethoxydiglycol allowed in the EU?

Dimethoxydiglycol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethoxydiglycol do in cosmetics?

Dimethoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-96-6 (bis(2-methoxyethyl) ether / diglyme).

What is the Margin of Safety for Dimethoxydiglycol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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