Chlorotrifluoropropene

CAS Number
102687-65-0 (trans-1-Chloro-3,3,3-trifluoropropene / HFO-1233zd)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CFCs are prohibited (21 CFR 700.23), but HFO-1233zd is not a CFC โ€” it is an HFO (hydrofluoroolefin) with ultra-low GWP; not specifically restricted by FDA for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Primarily an inhalation exposure concern; limited cosmetic safety dataset; environmental profile favorable with low ODP/GWP.

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Concern Level: Moderate

Frequently Asked Questions

Is Chlorotrifluoropropene safe in cosmetics?

Primarily an inhalation exposure concern; limited cosmetic safety dataset; environmental profile favorable with low ODP/GWP. The EU classifies Chlorotrifluoropropene as "permitted". Safety rating: MODERATE.

Is Chlorotrifluoropropene allowed in the EU?

Chlorotrifluoropropene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What is the Margin of Safety for Chlorotrifluoropropene?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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