Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Dimethyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2.5 other | 1995 | rat | inhalation | REACH |
| NOAEL | 1 other | 1994 | rat | inhalation | REACH |
| NOAEL | >=10000 ppm | 1994 | rat | inhalation | REACH |
| NOEL | 2000 ppm | 1994 | hamster | inhalation | REACH |
| NOAEL | >=20000 ppm | 1994 | rat | inhalation | REACH |
| NOEL | 10000 ppm | 1994 | hamster | inhalation | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Extremely flammable gas (GHS H220); CNS depression at high concentrations; inhalation exposure limits must be observed; not suitable for non-ventilated enclosed use; aerosol container pressure-testing required.
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Ether safe in cosmetics?
Extremely flammable gas (GHS H220); CNS depression at high concentrations; inhalation exposure limits must be observed; not suitable for non-ventilated enclosed use; aerosol container pressure-testing required. The EU classifies Dimethyl Ether as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Dimethyl Ether allowed in the EU?
Dimethyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Ether do in cosmetics?
Dimethyl Ether functions as: Solvent, propellant (aerosol formulations). It is classified as a cosmetic ingredient in our database. CAS number: 115-10-6.
What is the Margin of Safety for Dimethyl Ether?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Ether is 2.5 other based on a inhalation study via 1995 route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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