Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for 3-Methoxybutanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | 2400 | code:1952 | other | REACH |
| NOAEL | >=6 mg/L air | 1995 | rat | inhalation | REACH |
| NOAEL | 5 other | oral | rat | oral | REACH |
| NOAEL | >=6 mg/L air | inhalation | - | inhalation | REACH |
| NOEL | 10 other | oral | rat | oral | REACH |
| NOEL | 3 other | oral | dog | oral | REACH |
| NOAEL | 20 other | oral | rat | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Prohibited in EU cosmetics as a reproductive toxicant; glycol ether with developmental toxicity concerns. Not approved for fragrance use by IFRA. Restricted in US; risk assessment advised for all markets due to CMR classification.
Frequently Asked Questions
Is 3-Methoxybutanol safe in cosmetics?
Prohibited in EU cosmetics as a reproductive toxicant; glycol ether with developmental toxicity concerns. Not approved for fragrance use by IFRA. Restricted in US; risk assessment advised for all markets due to CMR classification. The EU classifies 3-Methoxybutanol as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database.
Is 3-Methoxybutanol allowed in the EU?
3-Methoxybutanol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Methoxybutanol do in cosmetics?
3-Methoxybutanol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 2517-43-3.
What is the Margin of Safety for 3-Methoxybutanol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 3-Methoxybutanol?
The NOAEL (No Observed Adverse Effect Level) for 3-Methoxybutanol is 100 mg/kg bw/day based on a other study via 2400 route in code:1952. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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