Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Isosorbide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 375 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Bio-renewable solvent and penetration-enhancing delivery vehicle with CIR 2023 safe-as-used assessment and no EU or US regulatory restrictions. Not classified as hazardous under CLP; non-sensitizing and non-irritating in cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Isosorbide safe in cosmetics?
Bio-renewable solvent and penetration-enhancing delivery vehicle with CIR 2023 safe-as-used assessment and no EU or US regulatory restrictions. Not classified as hazardous under CLP; non-sensitizing and non-irritating in cosmetic use. The EU classifies Dimethyl Isosorbide as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Dimethyl Isosorbide allowed in the EU?
Dimethyl Isosorbide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Isosorbide do in cosmetics?
Dimethyl Isosorbide functions as: Solvent, Viscosity Controlling, Penetration Enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 5306-85-4.
What is the Margin of Safety for Dimethyl Isosorbide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Isosorbide?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Isosorbide is 375 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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