Moderate Cosmetic Ingredient

Dimethylbutyl Crotonate

INCI: DIMETHYLBUTYL CROTONATE

CAS Number
35206-51-0
Function
Fragrance (perfuming agent)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not individually restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Structural alert: The crotonate moiety (2-butenoic acid ester) is an α,β-unsaturated carbonyl — a known Michael acceptor that can react with skin proteins. This raises theoretical sensitization concern even if no adverse data reported. Prioritize DPRA/KeratinoSens testing.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Dimethylbutyl Crotonate safe in cosmetics?

Structural alert: The crotonate moiety (2-butenoic acid ester) is an α,β-unsaturated carbonyl — a known Michael acceptor that can react with skin proteins. This raises theoretical sensitization concern even if no adverse data reported. Prioritize DPRA/KeratinoSens testing. The EU classifies Dimethylbutyl Crotonate as "permitted". Safety rating: MODERATE.

Is Dimethylbutyl Crotonate allowed in the EU?

Dimethylbutyl Crotonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethylbutyl Crotonate do in cosmetics?

Dimethylbutyl Crotonate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 35206-51-0.

What is the Margin of Safety for Dimethylbutyl Crotonate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Dimethylbutyl Crotonate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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