Is Ethyl Salicylate safe in cosmetics?
Ethyl Salicylate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Ethyl Salicylate
Also known as: 4-10-00-00149, BRN 0907659, EINECS 204-265-5, FEMA No. 2458, Sal ether (+11 more)
INCI: ETHYL SALICYLATE
Ethyl Salicylate (CAS 118-61-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; denaturant. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 118-61-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient; denaturant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
ethyl 2-hydroxybenzoate
InChIKey
GYCKQBWUSACYIF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Salicylate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
900
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL o-HYDROXYBENZOATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
SALICYLIC ETHER | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL SALICYLATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
SAL ETHER | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Salicylate.
Regulatory Flags
potential-allergen
fragrance-component
endocrine_disruptor
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-10-00-00149
BRN 0907659
EINECS 204-265-5
FEMA No. 2458
Sal ether
Salicyclic acid, ethyl ester
Salicylic ethyl ester
UNII-555U6TZ2MV
2-Hydroxyethylbenzoic acid
Benzoic acid, hydroxy-, ethyl ester
Ethyl hydroxybenzoate
Ethyl salicyclate
FEMA 2458
Methyl 2-hydroxybenzoate
Salicylic acid, ethyl ester
Salstan
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHYL SALICYLATE
ChEMBL ID
CHEMBL2251610
Frequently Asked Questions
Is Ethyl Salicylate allowed in the EU?
Ethyl Salicylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Salicylate do in cosmetics?
Ethyl Salicylate functions as: Fragrance ingredient; denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 118-61-6.
Is Ethyl Salicylate used outside cosmetics?
Ethyl Salicylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Salicylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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