Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dioctyldodecyl Sebacate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 630 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 178 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 630 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 178 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant safety concerns; hydrolysis products (sebacic acid, octyldodecanol) are well-tolerated. Ensure purity specifications exclude heavy metal contamination per standard cosmetic requirements.
Frequently Asked Questions
Is Dioctyldodecyl Sebacate safe in cosmetics?
No significant safety concerns; hydrolysis products (sebacic acid, octyldodecanol) are well-tolerated. Ensure purity specifications exclude heavy metal contamination per standard cosmetic requirements. The EU classifies Dioctyldodecyl Sebacate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Dioctyldodecyl Sebacate allowed in the EU?
Dioctyldodecyl Sebacate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dioctyldodecyl Sebacate do in cosmetics?
Dioctyldodecyl Sebacate functions as: Emollient, skin conditioning, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 69275-01-0.
What is the Margin of Safety for Dioctyldodecyl Sebacate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dioctyldodecyl Sebacate?
The NOAEL (No Observed Adverse Effect Level) for Dioctyldodecyl Sebacate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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