Moderate Cosmetic Ingredient NOAEL Data

Disodium Distyrylbiphenyl Disulfonate

INCI: DISODIUM DISTYRYLBIPHENYL DISULFONATE

CAS Number
27344-41-8
Function
UV Absorber, Hair Conditioning, Surfactant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not a monographed sunscreen active; listed on EPA TSCA inventory; no FDA-specific cosmetic restrictions; no CIR safety assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Disodium Distyrylbiphenyl Disulfonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 190 mg/kg bw/day oral rat oral REACH

Expert Verdict

Optical brightening agent with fluorescent whitening function; data-poor from cosmetic regulatory toxicology perspective with no SCCS opinion, CIR review, or dermal absorption study; eye irritation classification significant for facial and eye-area products.

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Concern Level: Moderate

Regulatory Flags

optical-brightener fluorescent-whitening uv-absorber synthetic data-gap no-sccs-opinion no-cir-review eye-irritant not-annex-vi industrial-use-primary

Frequently Asked Questions

Is Disodium Distyrylbiphenyl Disulfonate safe in cosmetics?

Optical brightening agent with fluorescent whitening function; data-poor from cosmetic regulatory toxicology perspective with no SCCS opinion, CIR review, or dermal absorption study; eye irritation classification significant for facial and eye-area products. The EU classifies Disodium Distyrylbiphenyl Disulfonate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Disodium Distyrylbiphenyl Disulfonate allowed in the EU?

Disodium Distyrylbiphenyl Disulfonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Distyrylbiphenyl Disulfonate do in cosmetics?

Disodium Distyrylbiphenyl Disulfonate functions as: UV Absorber, Hair Conditioning, Surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 27344-41-8.

What is the Margin of Safety for Disodium Distyrylbiphenyl Disulfonate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Disodium Distyrylbiphenyl Disulfonate?

The NOAEL (No Observed Adverse Effect Level) for Disodium Distyrylbiphenyl Disulfonate is 190 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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