Poor Cosmetic Ingredient NOAEL Data

Disperse Black 9

INCI: DISPERSE BLACK 9

CAS Number
12222-69-4
Function
Hair dyeing (non-oxidative)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not approved as a color additive under 21 CFR Parts 73/74; not permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Disperse Black 9. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 20 mg/kg bw/day oral rat Developmental COSMOS_DB

Expert Verdict

Contains 4-aminobiphenyl (4-ABP) at 4.35 ppm, classified as human carcinogen (IARC Group 1); prohibited in EU and US cosmetics.

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Concern Level: High

Frequently Asked Questions

Is Disperse Black 9 safe in cosmetics?

Contains 4-aminobiphenyl (4-ABP) at 4.35 ppm, classified as human carcinogen (IARC Group 1); prohibited in EU and US cosmetics. The EU classifies Disperse Black 9 as "prohibited". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Disperse Black 9 allowed in the EU?

Disperse Black 9 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Disperse Black 9 do in cosmetics?

Disperse Black 9 functions as: Hair dyeing (non-oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 12222-69-4.

What is the Margin of Safety for Disperse Black 9?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Disperse Black 9?

The NOAEL (No Observed Adverse Effect Level) for Disperse Black 9 is 20 mg/kg bw/day based on a Developmental study via oral route in rat. Source: COSMOS_DB.

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