Moderate Cosmetic Ingredient NOAEL Data

CI 10006

CAS Number
16143-80-9
Function
Colorant (green)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not FDA-listed for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for CI 10006. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2000 mg/kg bw/day oral rat oral REACH
NOAEL 1092 mg/kg bw/day oral rat oral REACH

Expert Verdict

Nitroso compound class with limited modern toxicological data and unclear FDA approval status for cosmetic colorant use.

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Concern Level: High

Regulatory Flags

colorant

Frequently Asked Questions

Is CI 10006 safe in cosmetics?

Nitroso compound class with limited modern toxicological data and unclear FDA approval status for cosmetic colorant use. The EU classifies CI 10006 as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is CI 10006 allowed in the EU?

CI 10006 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 10006 do in cosmetics?

CI 10006 functions as: Colorant (green). It is classified as a cosmetic ingredient in our database. CAS number: 16143-80-9.

What is the Margin of Safety for CI 10006?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 10006?

The NOAEL (No Observed Adverse Effect Level) for CI 10006 is 2000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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