Is Acid Yellow 73 Sodium Salt safe in cosmetics?
Acid Yellow 73 Sodium Salt has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Acid Yellow 73 Sodium Salt
Also known as: C.I. Acid yellow 73, Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium salt, Calcocid uranine B4315, 9-o-Carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt, Disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate (+12 more)
INCI: ACID YELLOW 73 SODIUM SALT
Acid Yellow 73 Sodium Salt (CAS 518-47-8) is a cosmetic cosmetic ingredient functioning as Colorant / Hair dye. Reported NOAEL =250 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 518-47-8 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant / Hair dye
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate
InChIKey
NJDNXYGOVLYJHP-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted as D&C Yellow No. 8 for externally applied drugs and cosmetics; 21 CFR 74.1708
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Yellow 73 Sodium Salt.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Acid Yellow 73 Sodium Salt. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg bw/day | oral | Rabbit | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =2241.4 mg/kg bw/day | injection | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Eye, skin, ... and/or respiratory tract irritation.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Acid Yellow 73 Sodium Salt.
Regulatory Flags
colorant
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Yellow 73 Sodium Salt by CAS number or substance name.
Studies
4
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
2241.4 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
C.I. Acid yellow 73
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium salt
Calcocid uranine B4315
9-o-Carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt
Disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate
EINECS 208-253-0
Fluorescein, soluble
Fluor-I-strip A.T.
Funduscein
NCI-C54706
Sodium salt of hydroxy-o-carboxy-phenyl-fluorone
Soluble fluoresceine
Uranine Yellow
Japan Yellow 202(1)
Funduscein-25
Ak-Fluor
UNII-93X55PE38X
Chemical Function
Dye
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
children; Europe; Personal care
pharmaceutical
Personal care
CEDI
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FLUORESCEIN SODIUM
ChEMBL ID
CHEMBL1628233
Max Phase
4
Adverse Event Associations
31
Frequently Asked Questions
Is Acid Yellow 73 Sodium Salt allowed in the EU?
Acid Yellow 73 Sodium Salt EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Yellow 73 Sodium Salt do in cosmetics?
Acid Yellow 73 Sodium Salt functions as: Colorant / Hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 518-47-8.
What is the NOAEL for Acid Yellow 73 Sodium Salt?
The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 73 Sodium Salt is =250 mg/kg bw/day based on a short-term study via oral route in Rabbit. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acid Yellow 73 Sodium Salt used outside cosmetics?
Acid Yellow 73 Sodium Salt also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Yellow 73 Sodium Salt compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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