Moderate Cosmetic Ingredient

Dodoxynol-12

INCI: DODOXYNOL-12

CAS Number
9014-92-0 (generic CAS for ethoxylated dodecylphenol series)
Function
Surfactant-emulsifying, cleansing
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Alkylphenol ethoxylate (APE) surfactant that degrades to dodecylphenol, a suspected endocrine disruptor; environmental concern and potential REACH supply chain impacts. Higher ethylene oxide number (12) improves water solubility and reduces irritation compared to lower homologs. Not COSMOS/ECOCERT eligible.

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Concern Level: Moderate

Frequently Asked Questions

Is Dodoxynol-12 safe in cosmetics?

Alkylphenol ethoxylate (APE) surfactant that degrades to dodecylphenol, a suspected endocrine disruptor; environmental concern and potential REACH supply chain impacts. Higher ethylene oxide number (12) improves water solubility and reduces irritation compared to lower homologs. Not COSMOS/ECOCERT eligible. The EU classifies Dodoxynol-12 as "restricted". Safety rating: MODERATE.

Is Dodoxynol-12 allowed in the EU?

Dodoxynol-12 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dodoxynol-12 do in cosmetics?

Dodoxynol-12 functions as: Surfactant-emulsifying, cleansing. It is classified as a cosmetic ingredient in our database. CAS number: 9014-92-0 (generic CAS for ethoxylated dodecylphenol series).

What is the Margin of Safety for Dodoxynol-12?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Dodoxynol-12 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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