Domiphen Bromide

INCI: DOMIPHEN BROMIDE

CAS Number
538-71-6
Function
Antimicrobial, Antiplaque, Deodorant, Oral Care
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.1%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics; also regulated as OTC drug active under FDA oral antiseptic monographs

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

OECD classified as Category 1 serious eye damage; quaternary ammonium compound requiring monitoring of mucosal irritation in oral care products; strict concentration compliance required; confirm no residual dimethylamine impurity

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Concern Level: Moderate

Frequently Asked Questions

Is Domiphen Bromide safe in cosmetics?

OECD classified as Category 1 serious eye damage; quaternary ammonium compound requiring monitoring of mucosal irritation in oral care products; strict concentration compliance required; confirm no residual dimethylamine impurity The EU classifies Domiphen Bromide as "restricted". Safety rating: MODERATE.

Is Domiphen Bromide allowed in the EU?

Domiphen Bromide EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.

What does Domiphen Bromide do in cosmetics?

Domiphen Bromide functions as: Antimicrobial, Antiplaque, Deodorant, Oral Care. It is classified as a cosmetic ingredient in our database. CAS number: 538-71-6.

What is the Margin of Safety for Domiphen Bromide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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