Moderate Cosmetic Ingredient GHS Classified

Ethoxyethanol Acetate

INCI: ETHOXYETHANOL ACETATE (2-ETHOXYETHANOL ACETATE)

CAS Number
111-15-9
Function
Solvent, viscosity decreasing agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not specifically banned by FDA but classified as a reproductive toxicant. Listed on California Proposition 65. Most US manufacturers avoid it voluntarily due to toxicity classification.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The vapour is mildly irritating to the eyes. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood. This may result in lesions of blood cells, anaemia and kidney impairment. May cause toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

Reproductive toxicity (Category 2 CMR); teratogenic effects demonstrated in animal studies; hematotoxicity. Norway banned it before the EU-wide prohibition. Classified as harmful by inhalation, ingestion, and skin absorption.. A glycol ether acetate that was valued for its excellent solvency and slow evaporation rate. Despite favorable technical properties, its severe reproductive toxicity profile led to regulatory elimination across most cosmetic markets.

⚠️
Concern Level: High

Regulatory Flags

prop65

Frequently Asked Questions

Is Ethoxyethanol Acetate safe in cosmetics?

Reproductive toxicity (Category 2 CMR); teratogenic effects demonstrated in animal studies; hematotoxicity. Norway banned it before the EU-wide prohibition. Classified as harmful by inhalation, ingestion, and skin absorption.. A glycol ether acetate that was valued for its excellent solvency and slow evaporation rate. Despite favorable technical properties, its severe reproductive toxicity profile led to regulatory elimination across most cosmetic markets. The EU classifies Ethoxyethanol Acetate as "prohibited". Safety rating: MODERATE.

Is Ethoxyethanol Acetate allowed in the EU?

Ethoxyethanol Acetate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethoxyethanol Acetate do in cosmetics?

Ethoxyethanol Acetate functions as: Solvent, viscosity decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 111-15-9.

What is the Margin of Safety for Ethoxyethanol Acetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Ethoxyethanol Acetate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

PEI-700
Good
Bis-Lauryldimoniumhydroxyethyl Bromide (PEG-220/SMDI Copolymer)
Moderate
Silica Cetyl Silylate
Good
Ericerus Pela Cera
Good
Tromethamine Magnesium Aluminum Silicate
Good
Browse all 30,000+ ingredients →
📱

Is Ethoxyethanol Acetate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ethoxyethanol Acetate in your formulation.

Ingredient Decoder MoS Calculator