Also known as: 5-19-07-00231, BRN 0130164, EINECS 229-114-0, Ethyl acetoacetate 3-ethylene acetal, Ethyl acetoacetate ethylene glycol ketal (+7 more)
INCI: ETHYLACETOACETATE ETHYLENE GLYCOL KETAL
Ethylacetoacetate Ethylene Glycol Ketal (CAS 6413-10-1) is a cosmetic cosmetic ingredient functioning as Fragrance with fresh, apple-like aroma. Reported NOAEL =1000 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylacetoacetate Ethylene Glycol Ketal.
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1 study endpoint found for Ethylacetoacetate Ethylene Glycol Ketal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ECHA |
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: HPPT: [687] Epstein WL (1978): Report to RIFM, 7 November, unpublished.
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
| HMT | - | 0 | 13500 | - | - |
| HRIPT | - | 0 | 581 | - | - |
| HRIPT | - | 0 | 11628 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for Ethylacetoacetate Ethylene Glycol Ketal — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Ethylacetoacetate Ethylene Glycol Ketal by CAS number or substance name.
Same-CAS public records found in food safety data.
Same-CAS food additive or FDA GRAS records from the core public database.
Ethylacetoacetate Ethylene Glycol Ketal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Ethylacetoacetate Ethylene Glycol Ketal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Ethylacetoacetate Ethylene Glycol Ketal functions as: Fragrance with fresh, apple-like aroma. It is classified as a cosmetic ingredient in our database. CAS number: 6413-10-1.
The NOAEL (No Observed Adverse Effect Level) for Ethylacetoacetate Ethylene Glycol Ketal is =1000 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ECHA.
Ethylacetoacetate Ethylene Glycol Ketal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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