Moderate Cosmetic Ingredient NOAEL Data

Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine

INCI: ETHYLHEXYL BIS-ISOPENTYLBENZOXAZOLYLPHENYL MELAMINE

CAS Number
288254-16-0
Function
UV absorber (optical brightener / UV light stabilizer); trade name Uvasorb K2A
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not FDA-approved as an OTC sunscreen active (not in 21 CFR 352); may be used as a product stabilizer, not as a sunscreen active

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1400 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Contains melamine triazine core โ€” assess for free melamine release. Not authorized as EU UV filter (Annex VI) โ€” cannot make sunscreen claims. High MW (764 Da) limits absorption but also limits published human safety data. Supplier dossier essential. If marketed as UV protection, regulatory non-compliance risk in both EU and US

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Concern Level: Moderate

Frequently Asked Questions

Is Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine safe in cosmetics?

Contains melamine triazine core โ€” assess for free melamine release. Not authorized as EU UV filter (Annex VI) โ€” cannot make sunscreen claims. High MW (764 Da) limits absorption but also limits published human safety data. Supplier dossier essential. If marketed as UV protection, regulatory non-compliance risk in both EU and US The EU classifies Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine allowed in the EU?

Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine do in cosmetics?

Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine functions as: UV absorber (optical brightener / UV light stabilizer); trade name Uvasorb K2A. It is classified as a cosmetic ingredient in our database. CAS number: 288254-16-0.

What is the Margin of Safety for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine?

The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Bis-Isopentylbenzoxazolylphenyl Melamine is 1400 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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