Fibroin

INCI: FIBROIN

CAS Number
9007-76-5
Function
Bulking agent; skin and hair conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR reviewed (2015 safety assessment of silk proteins); fibroin-based sutures are FDA-approved medical devices

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Animal-derived (silkworm Bombyx mori) incompatible with vegan claims; inhalation risk in powder/spray formulations; IgE-mediated hypersensitivity reported with surgical implantation but not typical cosmetic exposure; CIR noted fibroin not currently reported as used in cosmetics per VCRP.

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Concern Level: Low

Regulatory Flags

natural-origin

Frequently Asked Questions

Is Fibroin safe in cosmetics?

Animal-derived (silkworm Bombyx mori) incompatible with vegan claims; inhalation risk in powder/spray formulations; IgE-mediated hypersensitivity reported with surgical implantation but not typical cosmetic exposure; CIR noted fibroin not currently reported as used in cosmetics per VCRP. The EU classifies Fibroin as "permitted". Safety rating: GOOD.

Is Fibroin allowed in the EU?

Fibroin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Fibroin do in cosmetics?

Fibroin functions as: Bulking agent; skin and hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9007-76-5.

What is the Margin of Safety for Fibroin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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