Excellent Cosmetic Ingredient NOAEL Data

Collagen Extract

INCI: COLLAGEN

CAS Number
9007-34-5
Function
Hair conditioning, skin conditioning, humectant, moisturising, film forming
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA permitted; no restrictions. Must comply with 21 CFR ยง700.27 (prohibited cattle materials). GRAS for food peptones (21 CFR ยง184.1553)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Collagen Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 10000 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

BSE risk management required for bovine sources. Fish allergen labeling recommended for fish-sourced material. Heavy metals: <10 ppm metals, <1 ppm arsenic per supplier specifications. Max reported use: 96% in leave-on face/neck products

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Concern Level: Low

Regulatory Flags

plant-extract potential-allergen fda_food_additive

Frequently Asked Questions

Is Collagen Extract safe in cosmetics?

BSE risk management required for bovine sources. Fish allergen labeling recommended for fish-sourced material. Heavy metals: <10 ppm metals, <1 ppm arsenic per supplier specifications. Max reported use: 96% in leave-on face/neck products The EU classifies Collagen Extract as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Collagen Extract allowed in the EU?

Collagen Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Collagen Extract do in cosmetics?

Collagen Extract functions as: Hair conditioning, skin conditioning, humectant, moisturising, film forming. It is classified as a cosmetic ingredient in our database. CAS number: 9007-34-5.

What is the Margin of Safety for Collagen Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Collagen Extract?

The NOAEL (No Observed Adverse Effect Level) for Collagen Extract is 10000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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