Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Atelocollagen. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Animal-derived (typically bovine or porcine), raising BSE/TSE sourcing considerations - suppliers must provide certificates of origin from BSE-free countries; the telopeptide removal process significantly reduces immunogenicity compared to native collagen; acute oral toxicity LD50 > 20 mL/kg (rat). Produced by enzymatic (pepsin) treatment of native collagen to cleave the immunogenic telopeptide regions while preserving the triple-helix structure; lower molecular weight than intact collagen al...
Regulatory Flags
Frequently Asked Questions
Is Atelocollagen safe in cosmetics?
Animal-derived (typically bovine or porcine), raising BSE/TSE sourcing considerations - suppliers must provide certificates of origin from BSE-free countries; the telopeptide removal process significantly reduces immunogenicity compared to native collagen; acute oral toxicity LD50 > 20 mL/kg (rat). Produced by enzymatic (pepsin) treatment of native collagen to cleave the immunogenic telopeptide regions while preserving the triple-helix structure; lower molecular weight than intact collagen al... The EU classifies Atelocollagen as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Atelocollagen allowed in the EU?
Atelocollagen EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Atelocollagen do in cosmetics?
Atelocollagen functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9007-34-5.
What is the Margin of Safety for Atelocollagen?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Atelocollagen?
The NOAEL (No Observed Adverse Effect Level) for Atelocollagen is 10000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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