NOAEL Studies Fragrance

Galaxolide NOAEL Studies

INCI: HEXAMETHYLINDANOPYRAN

CAS: 1222-05-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >4640 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1797; row=13894; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-; preferred_name=1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran; dtxsid=DTXSID8027373; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027373; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1799; row=13895; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-; preferred_name=1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran; dtxsid=DTXSID8027373; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027373; source_file=acute_oral.xlsx
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4345; Record_ID=skin_sensitization_invivo_1050; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8027373; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80125-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027373
NTP ICE skin sensitization Induction dose per skin area 9720 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4343; Record_ID=skin_sensitization_invivo_1050; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8027373; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=9720; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80125-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027373
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4349; Record_ID=skin_sensitization_invivo_1050; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8027373; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80125-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027373
SCCNFP Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =50 mg/kg human dermal - dermal absorption p.7
ECHA 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =34 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6156; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15861539:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1284445094071772bda2119c0bc81f05
ECHA LOAEL =38 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6156; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15861346:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1d3f925a007e2a999448c8d822df72e
ECHA LOAEL =300 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca42e4b0a7c65d22117a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/6/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID:15850588:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a165ce2edc7a42dcd026cfb77fc2eb3
ECHA NOAEL =20 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6158; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15862010:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_880d3f0b43ce8174628b1cd9f7fb544e
ECHA NOAEL =30 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe88; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/3?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822454_15824136:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_98c14a207d3a5913d2fb52ac3c1243fb
ECHA NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe8a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/3?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15824133:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33a62e985ef0850c7057edcf8f6d0f94
ECHA NOAEL >=100 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe88; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/3?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821133_15824135:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1aa089bccea995c232ee6e0cc8016bf2
ECHA NOAEL <121 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6156; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861271_15862178:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c98294131b18133f6c22cf747ce6ade
ECHA NOAEL =150 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe8a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/3?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824134:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_50322c5659669db8a9a41ddc9a68c5cd
ECHA NOAEL =300 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe8c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/3?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821133_15824135:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9de19a483f810d44addae6e4e097aaee
ECHA NOAEL >=1650 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8a0e4b0a7c65d2197e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14504/7/9/2?documentUUID=d99ebc52-fafe-4997-a4e6-15d3cb8fcb52; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15857314:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4df7603d6ad1effa14fe4bbd2b0f9b5
ToxValDB EPA TSCA 8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA TSCA 8e LOAEL =150 mg/kg bw/day Rat oral short-term (developmental); 11 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000194_1222055_5B39AD01ABFB6E1B85256F8D004FB205.pdf; TOXICOLOGICAL_EFFECT=P0: reduced body weight, reduced food consumption; STUDY_GROUP=EPA TSCA 8e_dup_-_15957193_15957194_15957196_15957198:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d82e14280ad70115d833f1b50943a73
ToxValDB EPA TSCA 8e LOAEL =500 mg/kg bw/day Rat oral short-term (developmental); 11 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000194_1222055_5B39AD01ABFB6E1B85256F8D004FB205.pdf; TOXICOLOGICAL_EFFECT=P0: excess salivation, urine-stained abdominal fur, red or brown substance on the forepaws, and alopecia; STUDY_GROUP=EPA TSCA 8e_dup_-_15957193_15957194_15957196_15957198:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee3e4537aa118ec598cadbf29e533be5
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =13.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632485:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e14af35d1f98f873ad922e4518930d93
ToxValDB HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HPVIS LOAEL =300 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Api, AM and Ford, RA, 1999. Evaluation of the Oral Subchronic Toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran) in the Rat. Toxicology Letters, 111: 143-149.; TITLE=Evaluation of the Oral Subchronic Toxicity of HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran) in the Rat; AUTHOR=Api, AM and Ford, RA; QUALITY=1; EXTERNAL_SOURCE_ID=64054; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639054_15639475:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e09270220e6970b694278d91b9fd673d
Regulatory source 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 50 mg/kg - - - - p.7
Regulatory source dermal absorption =50 mg/kg human dermal - dermal absorption p.7
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 14170060AT UNII - - - chemical -