Gentiana Lutea Rhizome/Root Extract

INCI: GENTIANA LUTEA RHIZOME/ROOT EXTRACT

CAS Number
72968-42-4 / 97676-22-7; EINECS 277-139-0
Function
Skin conditioning, fragrance, antiseptic, microcirculation enhancer
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR; FDA UNII: S72O3284MS

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Gentiana lutea rhizome/root extract is permitted in both EU and US with good safety profile; EMA notes absence of reproductive toxicity and carcinogenicity testing; demonstrates antibacterial activity at 100 µg/mL in vitro and hepatoprotective effects at 30-60 mg/kg in animal studies with cytotoxicity only above 5 mM in vitro.

⚠️
Concern Level: Low

Regulatory Flags

plant-extract fragrance-component

Frequently Asked Questions

Is Gentiana Lutea Rhizome/Root Extract safe in cosmetics?

Gentiana lutea rhizome/root extract is permitted in both EU and US with good safety profile; EMA notes absence of reproductive toxicity and carcinogenicity testing; demonstrates antibacterial activity at 100 µg/mL in vitro and hepatoprotective effects at 30-60 mg/kg in animal studies with cytotoxicity only above 5 mM in vitro. The EU classifies Gentiana Lutea Rhizome/Root Extract as "permitted". Safety rating: GOOD.

Is Gentiana Lutea Rhizome/Root Extract allowed in the EU?

Gentiana Lutea Rhizome/Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gentiana Lutea Rhizome/Root Extract do in cosmetics?

Gentiana Lutea Rhizome/Root Extract functions as: Skin conditioning, fragrance, antiseptic, microcirculation enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 72968-42-4 / 97676-22-7; EINECS 277-139-0.

What is the Margin of Safety for Gentiana Lutea Rhizome/Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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