NOAEL Studies Fragrance

Geraniol NOAEL Studies

INCI: GERANIOL

CAS: 106-24-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 190 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 28 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=890d8152-6ba5-470d-8d08-149524eccde4
ECHA LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=890d8152-6ba5-470d-8d08-149524eccde4
ECHA LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=890d8152-6ba5-470d-8d08-149524eccde4
ECHA NOAEL 300 mg/kg bw/day rat - - repeated dose toxicity: dermal dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=ced74d29-7b77-470b-9215-c06b9ffeea52_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=ced74d29-7b77-470b-9215-c06b9ffeea52/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=2469eb55-df94-4ebb-a9a0-6c522a8fbaa4
ECHA NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=e11810df-0835-47cf-bf68-3ec1cc5843c1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=e11810df-0835-47cf-bf68-3ec1cc5843c1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=555ffa29-6747-4d68-8f45-ddfc75cfe50b
ECHA NOAEL 200 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; basis=body weight and weight gain; key_result=false; entry_uuid=231d47d4-4525-4432-b9ee-3f256295b4f9
ECHA NOAEL 800 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; key_result=false; entry_uuid=4b289db6-87fe-469c-b159-1e5389eb778b
ECHA NOAEL 60 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=9d078caf-7e6d-4631-beb8-116f617b6bbc
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=6db23e88-a3e9-4580-84da-ade58e30b061_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=6db23e88-a3e9-4580-84da-ade58e30b061/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-29; basis=other:; key_result=false; entry_uuid=1607e565-1ca4-44e8-aec7-7af28d5530d6
ECHA NOAEL 300 mg/kg bw/day rat - - repeated dose toxicity: dermal dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=ced74d29-7b77-470b-9215-c06b9ffeea52_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=ced74d29-7b77-470b-9215-c06b9ffeea52/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=2469eb55-df94-4ebb-a9a0-6c522a8fbaa4
ECHA NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=e11810df-0835-47cf-bf68-3ec1cc5843c1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=e11810df-0835-47cf-bf68-3ec1cc5843c1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=555ffa29-6747-4d68-8f45-ddfc75cfe50b
ECHA NOAEL 200 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; basis=body weight and weight gain; key_result=false; entry_uuid=231d47d4-4525-4432-b9ee-3f256295b4f9
ECHA NOAEL 800 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; key_result=false; entry_uuid=4b289db6-87fe-469c-b159-1e5389eb778b
ECHA NOAEL 60 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=9d078caf-7e6d-4631-beb8-116f617b6bbc
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=6db23e88-a3e9-4580-84da-ade58e30b061_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=6db23e88-a3e9-4580-84da-ade58e30b061/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-29; basis=other:; key_result=false; entry_uuid=1607e565-1ca4-44e8-aec7-7af28d5530d6
ECHA NOAEL 300 mg/kg bw/day rat - - repeated dose toxicity: dermal dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=ced74d29-7b77-470b-9215-c06b9ffeea52_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=ced74d29-7b77-470b-9215-c06b9ffeea52/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=2469eb55-df94-4ebb-a9a0-6c522a8fbaa4
ECHA NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=e11810df-0835-47cf-bf68-3ec1cc5843c1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=e11810df-0835-47cf-bf68-3ec1cc5843c1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=555ffa29-6747-4d68-8f45-ddfc75cfe50b
ECHA NOAEL 200 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; basis=body weight and weight gain; key_result=false; entry_uuid=231d47d4-4525-4432-b9ee-3f256295b4f9
ECHA NOAEL 800 mg/kg bw/day rat oral: gavage - extended one-generation reproductive toxicity - with F2 generation and both developmental neuro- and immunotoxicity (Cohorts 1A, 1B with extension, 2A, 2B, and 3) dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=4d839656-b02f-4155-b4c1-8dc38e3606d1_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=4d839656-b02f-4155-b4c1-8dc38e3606d1/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2021; ReportDate=2021-11-19; key_result=false; entry_uuid=4b289db6-87fe-469c-b159-1e5389eb778b
ECHA NOAEL 60 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=5d0a94e1-dfd7-4990-afcb-7cf9d9ae416d/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=9d078caf-7e6d-4631-beb8-116f617b6bbc
ECHA NOAEL 1000 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=6db23e88-a3e9-4580-84da-ade58e30b061_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=6db23e88-a3e9-4580-84da-ade58e30b061/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-29; basis=other:; key_result=false; entry_uuid=1607e565-1ca4-44e8-aec7-7af28d5530d6
ECHA NOEL >550 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=28155bfc-e004-40a0-83cc-be708a3baaa8_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=28155bfc-e004-40a0-83cc-be708a3baaa8/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; basis=other:; key_result=false; entry_uuid=e927be60-7d0b-4c23-9f5e-46ea5fc187b3
ECHA NOEL 2000 mg/kg bw/day rat oral: gavage - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=0ab2ece5-6796-4d54-a00a-ba4d6449f03b
ECHA NOEL >550 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=28155bfc-e004-40a0-83cc-be708a3baaa8_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=28155bfc-e004-40a0-83cc-be708a3baaa8/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; basis=other:; key_result=false; entry_uuid=e927be60-7d0b-4c23-9f5e-46ea5fc187b3
ECHA NOEL 2000 mg/kg bw/day rat oral: gavage - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=0ab2ece5-6796-4d54-a00a-ba4d6449f03b
ECHA NOEL >550 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=28155bfc-e004-40a0-83cc-be708a3baaa8_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=28155bfc-e004-40a0-83cc-be708a3baaa8/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; basis=other:; key_result=false; entry_uuid=e927be60-7d0b-4c23-9f5e-46ea5fc187b3
ECHA NOEL 2000 mg/kg bw/day rat oral: gavage - carcinogenicity: oral dossier=214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6z; document=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c_214f1b06-343c-4afa-a2c1-38c01a9a04f4.i6d; document_key=bbeb48ef-04f7-42e1-8fbc-e1f2c988bb9c/214f1b06-343c-4afa-a2c1-38c01a9a04f4; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=0ab2ece5-6796-4d54-a00a-ba4d6449f03b
ECHA NOAEL =300 mg/kg bw/day Rat dermal - developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1b4e4b0a7c65d22fc37; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/9/3?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15821427:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_096be91a08690b30d3d93d78f52a14c6
EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
EFSA NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
EFSA NOAEL =345 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15620041:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a8ff62eae72428c1c8c0a4c22a2e80a
NTP ICE acute dermal 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute dermal EPA classification 4 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2172; Record_ID=acute_dermal_444; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE acute dermal GHS classification 5 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2173; Record_ID=acute_dermal_444; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE acute dermal LD50 >5000 mg/kg Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2171; Record_ID=acute_dermal_444; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE acute inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation GHS Classification 4 unitless - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4633; Record_ID=acute_inhalation_363; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE acute inhalation LC50 >2.04 mg/L - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4632; Record_ID=acute_inhalation_363; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.04; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE acute oral 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral EPA classification =3 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13867; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Geraniol; preferred_name=Geraniol; percent_active_ingredient=17.28; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral GHS classification =4 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13866; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Geraniol; preferred_name=Geraniol; percent_active_ingredient=17.28; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >2840 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_528; row=13860; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >2900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_536; row=13861; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_539; row=13862; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <4570 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_540; row=13863; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_541; row=13864; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <5900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_544; row=13865; data_type=In Vivo; mixture=Chemical; chemical_name=Geraniol; preferred_name=Geraniol; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1750 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13868; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Geraniol; preferred_name=Geraniol; percent_active_ingredient=17.28; dtxsid=DTXSID8026727; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727; source_file=acute_oral.xlsx
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9974; RecordID=ARPathway2016_467; DatasetName=ARPathway2016; DTXSID=DTXSID8026727; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE eye irritation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2470; Record_ID=eye_irritation_1026; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID874; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE eye irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2470; Record_ID=eye_irritation_1026; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID874; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE eye irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2470; Record_ID=eye_irritation_1026; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID874; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE eye irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2470; Record_ID=eye_irritation_1026; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID874; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin irritation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation EPA classification 3 unitless Rabbit Dermal - In Vivo; Draize Skin Irritation/Corrosion Test sheet=Data_invivo; excel_row=1653; Record_ID=skin_irritation_invivo_503; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=17.28; Mixture=Mixture; DTXSID=DTXSID8026727; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin irritation Positive reaction 17.9 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1651; Record_ID=skin_irritation_invivo_11; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=17.90; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization 53 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 123.03 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2131; Record_ID=skin_sensitization_invitro_528; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=123.03; Reported_Response_Unit=ug/mL; Response=123.03; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CD86, EC150 123.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2715; Record_ID=skin_sensitization_invitro_637; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=123.3; Reported_Response_Unit=ug/mL; Response=123.3; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CD86, EC150 46.708 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8210; Record_ID=skin_sensitization_invitro_2233; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=302.8; Reported_Response_Unit=uM; Conversion_Factor_Value=154.253; Conversion_Factor_Source=EPA Dashboard; Converted_Response=46.708; Converted_Response_Unit=ug/mL; Response=46.708; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CD86, EC150 53.62 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8615; Record_ID=skin_sensitization_invitro_2381; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=53.62; Reported_Response_Unit=ug/mL; Response=53.62; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CV70 133.85 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8613; Record_ID=skin_sensitization_invitro_2381; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=U-SENS; Endpoint=CV70; Reported_Response=133.85; Reported_Response_Unit=ug/mL; Response=133.85; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CV75 139.2 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2132; Record_ID=skin_sensitization_invitro_528; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=h-CLAT; Endpoint=CV75; Reported_Response=139.19999999999999; Reported_Response_Unit=ug/mL; Response=139.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization CV75 140 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2716; Record_ID=skin_sensitization_invitro_637; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=h-CLAT; Endpoint=CV75; Reported_Response=140; Reported_Response_Unit=ug/mL; Response=140; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 7.8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2961; Record_ID=skin_sensitization_invivo_781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=7.8; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.3125 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2981; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.3125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 18.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2998; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=18.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, one positive response 6 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2957; Record_ID=skin_sensitization_invivo_781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=6; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, one positive response 0.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2976; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Concentration, one positive response 5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2996; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Cys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=569; Record_ID=skin_sensitization_invitro_166; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Cys -3.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=579; Record_ID=skin_sensitization_invitro_168; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-3.1; Reported_Response_Unit=%; Response=-3.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Lys 10 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=567; Record_ID=skin_sensitization_invitro_166; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=10; Reported_Response_Unit=%; Response=10; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Lys 0.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=576; Record_ID=skin_sensitization_invitro_168; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Lys + Cys 5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=572; Record_ID=skin_sensitization_invitro_166; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5; Reported_Response_Unit=%; Response=5; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Depletion Lys + Cys 0.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=581; Record_ID=skin_sensitization_invitro_168; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC1.5 110 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4366; Record_ID=skin_sensitization_invitro_1013; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=110; Reported_Response_Unit=uM; Response=110; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Natsch personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC1.5 209.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4367; Record_ID=skin_sensitization_invitro_1015; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=209.8; Reported_Response_Unit=uM; Response=209.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4368; Record_ID=skin_sensitization_invitro_1013; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Natsch personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 11.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13267; Record_ID=skin_sensitization_invivo_3349; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=11.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 26 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13272; Record_ID=skin_sensitization_invivo_3356; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=26; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 11.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13267; Record_ID=skin_sensitization_invivo_3349; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=11.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 26 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13272; Record_ID=skin_sensitization_invivo_3356; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=26; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 11.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13267; Record_ID=skin_sensitization_invivo_3349; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=11.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 26 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13272; Record_ID=skin_sensitization_invivo_3356; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=26; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 11.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13267; Record_ID=skin_sensitization_invivo_3349; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=11.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Lalko and Api 2006; 16324777; 10.1016/j.fct.2005.10.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization EC3 26 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13272; Record_ID=skin_sensitization_invivo_3356; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=LLNA; Endpoint=EC3; Response=26; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization IC50 722 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4369; Record_ID=skin_sensitization_invitro_1015; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=722; Reported_Response_Unit=uM; Response=722; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization IC50 875 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4370; Record_ID=skin_sensitization_invitro_1013; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=875; Reported_Response_Unit=uM; Response=875; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Natsch personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Imax 2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4372; Record_ID=skin_sensitization_invitro_1015; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2; Reported_Response_Unit=Unitless; Response=2; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Imax 2.05 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4373; Record_ID=skin_sensitization_invitro_1013; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.0499999999999998; Reported_Response_Unit=Unitless; Response=2.05; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Natsch personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2943; Record_ID=skin_sensitization_invivo_778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Incidence of positive responses 3.846 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2952; Record_ID=skin_sensitization_invivo_781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=3.846; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Incidence of positive responses 80 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2973; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=80; Response_Unit=%; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Incidence of positive responses 2.74 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2994; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.74; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 4050 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2941; Record_ID=skin_sensitization_invivo_778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4050; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 2362 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2968; Record_ID=skin_sensitization_invivo_783; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=2362; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2000; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 3240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2971; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 3100 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2977; Record_ID=skin_sensitization_invivo_785; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 7087 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2984; Record_ID=skin_sensitization_invivo_786; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=7087; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 3724 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2987; Record_ID=skin_sensitization_invivo_787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3724; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90165-5|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Akkan et al. 2003; Not available; Not available|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 6299 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2993; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6299; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area 7750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3004; Record_ID=skin_sensitization_invivo_790; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=7750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 5265 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2964; Record_ID=skin_sensitization_invivo_781; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=5265; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 202.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2983; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=202.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 11500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3000; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=11500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area, one positive response 162 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2978; Record_ID=skin_sensitization_invivo_784; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=162; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Opdyke personal communication 1974|Malten et al. 1984; 6378513; 10.1111/j.1600-0536.1984.tb00162.x|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Induction dose per skin area, one positive response 3150 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2997; Record_ID=skin_sensitization_invivo_788; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=3150; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2948; Record_ID=skin_sensitization_invivo_778; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
NTP ICE skin sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2991; Record_ID=skin_sensitization_invivo_787; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026727; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90165-5|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640215; 10.1016/j.fct.2008.06.048|Akkan et al. 2003; Not available; Not available|Hostynek and Maibach 2004; Not available; 10.1159/000092824|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026727
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =11.8 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631430:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2826aa5a8a71920fbd046da060a024ce
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier L837108USY UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L837108USY"}
openFDA substances FDA UNII substance identifier L837108USY UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L837108USY"}
openFDA substances FDA UNII substance identifier L837108USY UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L837108USY"}
openFDA substances FDA UNII substance identifier L837108USY UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L837108USY"}