Moderate Fragrance NOAEL Data Sensitization Data Dermal Penetration

Geraniol

INCI: GERANIOL

CAS Number
106-24-1
Function
fragrance; antimicrobial
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 10 ppm in leave-on products, 100 ppm in rinse-off products
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No US federal individual fragrance ingredient disclosure requirement; listed as fragrance only under FDA rules

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Geraniol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 50 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOEL >10000 ppm oral rat oral REACH
NOAEL 300 mg/kg bw/day dermal rat dermal REACH

Sensitization Profile

Contact sensitization data for Geraniol based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.1%
Cross-reactivity Group
fragrance-mix-I
Reaction Type
contact-dermatitis
IFRA Restricted โ€” max 5.0% in finished products

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Geraniol, relevant to systemic exposure and MoS calculations.

Absorption %
18-32%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
154.3 Da
Log P
3.28
Systemic Absorption
yes
Topical Bioavailability
12-28%
Safety Margin Factor
high
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

EU 26 declared allergen requiring individual label declaration on EU cosmetic labels above threshold concentrations; restrictions apply equally to natural and synthetic sources.

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Concern Level: Moderate

Regulatory Flags

eu-26-allergen label-declaration-required contact-allergen natural-origin eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed jecfa_safe

Frequently Asked Questions

Is Geraniol safe in cosmetics?

EU 26 declared allergen requiring individual label declaration on EU cosmetic labels above threshold concentrations; restrictions apply equally to natural and synthetic sources. The EU classifies Geraniol as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is Geraniol allowed in the EU?

Geraniol EU regulatory status: restricted. Maximum allowed concentration: 10 ppm in leave-on products, 100 ppm in rinse-off products. This is based on EU Regulation 1223/2009 and its amendments.

What does Geraniol do in cosmetics?

Geraniol functions as: fragrance; antimicrobial. It is classified as a Fragrance in our database. CAS number: 106-24-1.

What is the Margin of Safety for Geraniol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Geraniol?

The NOAEL (No Observed Adverse Effect Level) for Geraniol is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.

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