Gluconolactone
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Gluconolactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 695 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 594 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 560 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 780 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 695 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 594 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 560 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| dose_tested | 780 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Gluconolactone, relevant to systemic exposure and MoS calculations.
Source: Dermatol Surg 2004
Expert Verdict
Gluconolactone is the premier PHA, offering comparable antiaging and exfoliating efficacy to glycolic acid with substantially superior tolerability, no photosensitivity, and added antioxidant and humectant activity. The preferred exfoliant for sensitive skin, Fitzpatrick IV–VI, post-procedure skin, and rosacea.
Regulatory Flags
Frequently Asked Questions
Is Gluconolactone safe in cosmetics?
Gluconolactone is the premier PHA, offering comparable antiaging and exfoliating efficacy to glycolic acid with substantially superior tolerability, no photosensitivity, and added antioxidant and humectant activity. The preferred exfoliant for sensitive skin, Fitzpatrick IV–VI, post-procedure skin, and rosacea. The EU classifies Gluconolactone as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Gluconolactone allowed in the EU?
Gluconolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gluconolactone do in cosmetics?
Gluconolactone functions as: Antioxidant; Chelating agent; Chemical reaction regulator; Flavouring and nutrient; Food preservative; Fragrance; Humectant; Leavening agent; Preservative; Processing aids not otherwise specified; Softener and conditioner; Solvent; pH regulating agent. It is classified as a Active Ingredient in our database. CAS number: 90-80-2.
What is the Margin of Safety for Gluconolactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Gluconolactone?
The NOAEL (No Observed Adverse Effect Level) for Gluconolactone is 500 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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