Is Tazarotene & Tazarotenic Acid Report safe in cosmetics?
Tazarotene & Tazarotenic Acid Report has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Tazarotene & Tazarotenic Acid Report
Also known as: Tazorac, UNII-81BDR9Y8PS
INCI: TAZAROTENE
Tazarotene & Tazarotenic Acid Report (CAS 118292-40-3) is a cosmetic active ingredient functioning as active ingredient. EU Regulation 1223/2009 status: permitted, max 1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 118292-40-3 →
Auto-generated CPSR Part A draft with source citations
Function
active ingredient
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
1%
US US Status
permitted
US Notes
South Korea revised cosmetic safety standards in September 2025 per Ministry of Food and Drug Safety announcement.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tazarotene & Tazarotenic Acid Report.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "118292-40-3", "anti_acne_mechanism": "keratolytic/comedolytic/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "p_acnes_mic_ug_per_ml": "No direct antibacterial", "sebum_reduction_pct_clinical": "10-15", "keratolytic_strength": "strong", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "5.0-7.0", "peel_de…
anti_aging
{"anti_aging_claim": "anti-wrinkle, firming, pore-minimizing, cell-turnover", "mechanism_of_action": "Third-generation retinoid, RAR-beta/gamma selective, potent collagen induction", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Very high", "elastin_protection": "Yes", "wrinkle_reduction_pct": "28-38", "clinical_study_duration_weeks": "24", "sample_size": "568", "double_blind"…
pregnancy_detail
{"pregnancy_safe": "no", "breastfeeding_safe": "no", "trimester_restriction": "all", "risk_category": "FDA-X", "reason": "Teratogenic retinoid", "alternative_ingredient": "Azelaic Acid", "source": "FDA; AAD"}
skin_suitability
{"oily_skin": "recommended", "dry_skin": "caution", "sensitive_skin": "avoid", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "recommended", "rosacea": "avoid", "eczema": "avoid", "hyperpigmentation": "recommended", "aging_mature": "recommended", "dehydrated": "avoid", "skin_benefit_primary": "acne-treatment", "skin_benefit_secondary": "anti-aging", "mechanism_of_acti…
uv_stability
{"uv_stable": "no", "uv_degradation_rate": "fast", "photosensitizer": "yes", "phototoxic": "yes", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "yes", "odor_change_uv": "yes", "efficacy_loss_uv_pct": "60", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tazarotene & Tazarotenic Acid Report.
Known Synonyms
Tazorac
UNII-81BDR9Y8PS
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TAZAROTENE
ChEMBL ID
CHEMBL1657
Max Phase
4
Adverse Event Associations
133
Frequently Asked Questions
Is Tazarotene & Tazarotenic Acid Report allowed in the EU?
Tazarotene & Tazarotenic Acid Report EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tazarotene & Tazarotenic Acid Report do in cosmetics?
Tazarotene & Tazarotenic Acid Report functions as: active ingredient. It is classified as a Active Ingredient in our database. CAS number: 118292-40-3.
Is Tazarotene & Tazarotenic Acid Report used outside cosmetics?
Tazarotene & Tazarotenic Acid Report also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tazarotene & Tazarotenic Acid Report compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Antioxidant
Tazarotene
Moderate
Chemical family
skin-conditioning, anti-aging
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Good
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