Glycerophosphocholine

INCI: GLYCEROPHOSPHOCHOLINE

CAS Number
28319-77-9
Function
Skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction; not prohibited under 21 CFR 700

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endogenous phospholipid metabolite with strong general safety profile; limited cosmetic-specific dermal toxicity studies; GHS classification H315/H319/H335 applies to bulk chemical, not typical cosmetic use concentrations.

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Concern Level: Low

Frequently Asked Questions

Is Glycerophosphocholine safe in cosmetics?

Endogenous phospholipid metabolite with strong general safety profile; limited cosmetic-specific dermal toxicity studies; GHS classification H315/H319/H335 applies to bulk chemical, not typical cosmetic use concentrations. The EU classifies Glycerophosphocholine as "permitted". Safety rating: GOOD.

Is Glycerophosphocholine allowed in the EU?

Glycerophosphocholine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycerophosphocholine do in cosmetics?

Glycerophosphocholine functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 28319-77-9.

What is the Margin of Safety for Glycerophosphocholine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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