Glyceryl Di-Hydroxystearate

INCI: GLYCERYL DIHYDROXYSTEARATE

CAS Number
122546-20-7
Function
Skin conditioning agent — emollient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR Expert Panel: safe as a cosmetic ingredient provided the 1,2-diester content is not high enough to cause epidermal hyperplasia (IJT 2007;26 Suppl 3:1-30)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

1,2-diester isomer content must be controlled — potential for PKC activation and epidermal hyperplasia if 1,2-isomer proportion is high. Not reported in current commercial use as of 2022.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Glyceryl Di-Hydroxystearate safe in cosmetics?

1,2-diester isomer content must be controlled — potential for PKC activation and epidermal hyperplasia if 1,2-isomer proportion is high. Not reported in current commercial use as of 2022. The EU classifies Glyceryl Di-Hydroxystearate as "permitted". Safety rating: GOOD.

Is Glyceryl Di-Hydroxystearate allowed in the EU?

Glyceryl Di-Hydroxystearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glyceryl Di-Hydroxystearate do in cosmetics?

Glyceryl Di-Hydroxystearate functions as: Skin conditioning agent — emollient. It is classified as a cosmetic ingredient in our database. CAS number: 122546-20-7.

What is the Margin of Safety for Glyceryl Di-Hydroxystearate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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