Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Glyceryl Thioglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2 other | dermal | code:3484 | dermal | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Prohibited in EU since July 2013 on eyelashes; permitted in US with monitoring. Mandatory professional-use labeling at >8%; sensitization and irritation risk increase with prolonged contact and alkaline pH. Patch testing recommended.
Regulatory Flags
Frequently Asked Questions
Is Glyceryl Thioglycolate safe in cosmetics?
Prohibited in EU since July 2013 on eyelashes; permitted in US with monitoring. Mandatory professional-use labeling at >8%; sensitization and irritation risk increase with prolonged contact and alkaline pH. Patch testing recommended. The EU classifies Glyceryl Thioglycolate as "prohibited". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Glyceryl Thioglycolate allowed in the EU?
Glyceryl Thioglycolate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Glyceryl Thioglycolate do in cosmetics?
Glyceryl Thioglycolate functions as: Hair waving/straightening agent (thioglycolic acid ester). It is classified as a cosmetic ingredient in our database. CAS number: 30618-84-9.
What is the Margin of Safety for Glyceryl Thioglycolate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glyceryl Thioglycolate?
The NOAEL (No Observed Adverse Effect Level) for Glyceryl Thioglycolate is 2 other based on a dermal study via dermal route in code:3484. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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