Is Guaiacol Phenylacetate safe in cosmetics?
Guaiacol Phenylacetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Guaiacol Phenylacetate
Also known as: Acetic acid, phenyl-, O-methoxyphenyl ester, EINECS 223-898-8, FEMA No. 2535, Methoxyphenyl phenylacetate, o-, Methylcatechol acetate, o- (+1 more)
INCI: GUAIACYL PHENYLACETATE
Guaiacol Phenylacetate (CAS 4112-89-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4112-89-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2-methoxyphenyl) 2-phenylacetate
InChIKey
KNVYLIIBQXVDKC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guaiacol Phenylacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
719
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
GUAIACYL PHENYLACETATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Guaiacol Phenylacetate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Acetic acid, phenyl-, O-methoxyphenyl ester
EINECS 223-898-8
FEMA No. 2535
Methoxyphenyl phenylacetate, o-
Methylcatechol acetate, o-
UNII-LLO759386W
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Guaiacol Phenylacetate allowed in the EU?
Guaiacol Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guaiacol Phenylacetate do in cosmetics?
Guaiacol Phenylacetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 4112-89-4.
Is Guaiacol Phenylacetate used outside cosmetics?
Guaiacol Phenylacetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guaiacol Phenylacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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