Guaiacol Phenylacetate

INCI: GUAIACYL PHENYLACETATE

CAS Number
4112-89-4
Function
Fragrance ingredient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not genotoxic or phototoxic; cleared at RIFM screening level for environmental endpoints; safety supported by read-across to guaiacol and phenylacetic acid despite limited direct in vivo data.

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Guaiacol Phenylacetate safe in cosmetics?

Not genotoxic or phototoxic; cleared at RIFM screening level for environmental endpoints; safety supported by read-across to guaiacol and phenylacetic acid despite limited direct in vivo data. The EU classifies Guaiacol Phenylacetate as "permitted". Safety rating: GOOD.

Is Guaiacol Phenylacetate allowed in the EU?

Guaiacol Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Guaiacol Phenylacetate do in cosmetics?

Guaiacol Phenylacetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 4112-89-4.

What is the Margin of Safety for Guaiacol Phenylacetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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