Moderate Cosmetic Ingredient

Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer

INCI: GUANIDINE CARBONATE/HDI ISOCYANURATE TRIMER/MDI CROSSPOLYMER

CAS Number
Not assigned (polymeric composite)
Function
Film forming / texture modifier (crosspolymer)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — polymers not individually listed; subject to general safety under FD&C Act

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

HDI (hexamethylene diisocyanate) and MDI (methylene diphenyl diisocyanate) monomers are potent sensitizers and respiratory hazards. Residual monomer levels must be certified below regulatory limits. Batch-specific Certificate of Analysis for free isocyanate content is mandatory. No published SCCS/CIR opinion available.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer safe in cosmetics?

HDI (hexamethylene diisocyanate) and MDI (methylene diphenyl diisocyanate) monomers are potent sensitizers and respiratory hazards. Residual monomer levels must be certified below regulatory limits. Batch-specific Certificate of Analysis for free isocyanate content is mandatory. No published SCCS/CIR opinion available. The EU classifies Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer as "permitted". Safety rating: MODERATE.

Is Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer allowed in the EU?

Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer do in cosmetics?

Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer functions as: Film forming / texture modifier (crosspolymer). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (polymeric composite).

What is the Margin of Safety for Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Guanidine Carbonate/HDI Isocyanurate Trimer/MDI Crosspolymer compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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