Is HC Violet No. 1 safe in cosmetics?
HC Violet No. 1 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
HC Violet No. 1
Also known as: UNII-0R7XO4T22K, 4-Amino-3-methyl-4-(2-hydroxyethyl)amino-6-nitrobenzene, Ethanol, 2-((4-amino-2-methyl-5-nitrophenyl)amino)-, HC Violet 1, Imexine FAA
INCI: HC VIOLET NO. 1
HC Violet No. 1 (CAS 82576-75-8) is a cosmetic cosmetic ingredient functioning as Hair dyeing (non-oxidative/semi-permanent). Reported NOAEL =800 mg/kg bw/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 82576-75-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Violet No. 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (non-oxidative/semi-permanent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(4-amino-2-methyl-5-nitroanilino)ethanol
InChIKey
LGZSBRSLVPLNTM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Violet No. 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for HC Violet No. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =800 mg/kg bw/day | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =800 mg/kg bw/day | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =800 mg/kg bw/day | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =800 mg/kg bw/day | oral | rat | NOAEL study | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 0.28%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.28%
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_hair_dye | - | Direct hair dye |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 2.0% | - | - | SCCP/0063 |
| measured | 97.26% | - | - | SCCP/0063 |
| measured | 98.4% | - | - | SCCP/0063 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "82576-75-8", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "226.23", "color_result_on_hair": "Violet", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "modera…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Violet No. 1.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Violet No. 1 by CAS number or substance name.
Studies
4
Lowest NOAEL
800 mg/kg bw/day
Highest NOAEL
800 mg/kg bw/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.0% | - | - |
| 97.26% | - | - |
| 98.4% | - | - |
Known Synonyms
UNII-0R7XO4T22K
4-Amino-3-methyl-4-(2-hydroxyethyl)amino-6-nitrobenzene
Ethanol, 2-((4-amino-2-methyl-5-nitrophenyl)amino)-
HC Violet 1
Imexine FAA
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Violet No. 1 allowed in the EU?
HC Violet No. 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Violet No. 1 do in cosmetics?
HC Violet No. 1 functions as: Hair dyeing (non-oxidative/semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 82576-75-8.
What is the NOAEL for HC Violet No. 1?
The NOAEL (No Observed Adverse Effect Level) for HC Violet No. 1 is =800 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 4 study endpoints are available. Source: SCCS_vision_codex.
Is HC Violet No. 1 used outside cosmetics?
HC Violet No. 1 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Violet No. 1 have different safety status in cosmetics vs industrial chemicals?
HC Violet No. 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Compliance Tools
Check HC Violet No. 1 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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