Moderate Cosmetic Ingredient Sensitization Data

HC Yellow No. 12

INCI: HC YELLOW NO. 12

CAS Number
59320-13-7 *(verify against CosIng)*
Function
Semi-permanent direct hair dye, nitro dye class
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted under coal-tar hair dye exemption under FD&C Act Section 601(a)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for HC Yellow No. 12 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: SCCS; IVDK

Expert Verdict

Prohibited in EU due to nitrosamine formation risk from secondary amine structure; permitted in US under coal-tar hair dye exemption; insufficient margin of safety data for regulatory dossier completion.

⚠️
Concern Level: Moderate

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is HC Yellow No. 12 safe in cosmetics?

Prohibited in EU due to nitrosamine formation risk from secondary amine structure; permitted in US under coal-tar hair dye exemption; insufficient margin of safety data for regulatory dossier completion. The EU classifies HC Yellow No. 12 as "prohibited". Safety rating: MODERATE.

Is HC Yellow No. 12 allowed in the EU?

HC Yellow No. 12 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Yellow No. 12 do in cosmetics?

HC Yellow No. 12 functions as: Semi-permanent direct hair dye, nitro dye class. It is classified as a cosmetic ingredient in our database. CAS number: 59320-13-7 *(verify against CosIng)*.

What is the Margin of Safety for HC Yellow No. 12?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check HC Yellow No. 12 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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