Hemocyanin

INCI: HEMOCYANIN

CAS Number
9013-72-3
Function
Anti-sebum, antimicrobial
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR restriction. KLH variant used in pharmaceuticals follows separate regulatory pathway.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

KLH (keyhole limpet hemocyanin) is a classical immunogen and adjuvant. Topical application to intact skin is unlikely to trigger systemic immune response due to molecular size, but compromised-barrier use poses high risk. Animal-origin ingredient requires TSE/BSE-equivalent risk assessment for invertebrate sourcing. Shellfish allergy cross-reactivity not established but warrants labeling consideration.

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Concern Level: High

Frequently Asked Questions

Is Hemocyanin safe in cosmetics?

KLH (keyhole limpet hemocyanin) is a classical immunogen and adjuvant. Topical application to intact skin is unlikely to trigger systemic immune response due to molecular size, but compromised-barrier use poses high risk. Animal-origin ingredient requires TSE/BSE-equivalent risk assessment for invertebrate sourcing. Shellfish allergy cross-reactivity not established but warrants labeling consideration. The EU classifies Hemocyanin as "permitted". Safety rating: MODERATE.

Is Hemocyanin allowed in the EU?

Hemocyanin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hemocyanin do in cosmetics?

Hemocyanin functions as: Anti-sebum, antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 9013-72-3.

What is the Margin of Safety for Hemocyanin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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