Hexamethylenediamine/MDI Copolymer

INCI: HEXAMETHYLENEDIAMINE/MDI COPOLYMER

CAS Number
Not assigned (polymer — exempt from CAS pre-registration under REACH polymer exemption)
Function
Film forming
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — CIR reviewed HDI/diisocyanate polymers as a class and found them safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Free diisocyanate monomers (MDI) cause occupational asthma and skin sensitization; hexamethylenediamine is a strong skin/respiratory sensitizer. Residual monomer specification must be documented in CPSR. Inhalation exposure route is critical—avoid use in spray products unless residual monomer data confirms safety.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hexamethylenediamine/MDI Copolymer safe in cosmetics?

Free diisocyanate monomers (MDI) cause occupational asthma and skin sensitization; hexamethylenediamine is a strong skin/respiratory sensitizer. Residual monomer specification must be documented in CPSR. Inhalation exposure route is critical—avoid use in spray products unless residual monomer data confirms safety. The EU classifies Hexamethylenediamine/MDI Copolymer as "prohibited". Safety rating: GOOD.

Is Hexamethylenediamine/MDI Copolymer allowed in the EU?

Hexamethylenediamine/MDI Copolymer EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexamethylenediamine/MDI Copolymer do in cosmetics?

Hexamethylenediamine/MDI Copolymer functions as: Film forming. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (polymer — exempt from CAS pre-registration under REACH polymer exemption).

What is the Margin of Safety for Hexamethylenediamine/MDI Copolymer?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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