Is Human Placental Extract safe in cosmetics?
Human Placental Extract has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Human Placental Extract
INCI: HUMAN PLACENTAL EXTRACT
Human Placental Extract (CAS 85085-41-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning, humectant. Reported NOAEL =207 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 85085-41-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Human Placental Extract is prohibited in EU cosmetics but has active industrial GHS classifications (H304, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning, humectant
Safety Rating
MODERATE
Chemistry & Identifiers
EC Number
285-370-3
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; longest commercial history of all 10 ingredients
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Human Placental Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Human Placental Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =207 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Human Placental Extract.
Regulatory Flags
plant-extract
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Human Placental Extract by CAS number or substance name.
Studies
1
Lowest NOAEL
207 mg/kg bw/day
Highest NOAEL
207 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Humectant
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Human Placental Extract allowed in the EU?
Human Placental Extract EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Human Placental Extract do in cosmetics?
Human Placental Extract functions as: Skin conditioning, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 85085-41-2.
What is the NOAEL for Human Placental Extract?
The NOAEL (No Observed Adverse Effect Level) for Human Placental Extract is =207 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Human Placental Extract used outside cosmetics?
Human Placental Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Human Placental Extract have different safety status in cosmetics vs industrial chemicals?
Human Placental Extract is prohibited in EU cosmetics but has active industrial GHS classifications (H304, H400, H410).
Compliance Tools
Check Human Placental Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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