Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hydrolyzed Potato Protein. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1420 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 284.5 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 2500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
Expert Verdict
Molecular weight control is critical; ensure supplier provides MW distribution data and confirms weight-average ≤ 3500 Da. Generally well-tolerated; potato is not a major allergen under EU FIC but IgE reactivity to patatin (potato allergen) exists. CIR concluded safe in present practices of use.
Regulatory Flags
Frequently Asked Questions
Is Hydrolyzed Potato Protein safe in cosmetics?
Molecular weight control is critical; ensure supplier provides MW distribution data and confirms weight-average ≤ 3500 Da. Generally well-tolerated; potato is not a major allergen under EU FIC but IgE reactivity to patatin (potato allergen) exists. CIR concluded safe in present practices of use. The EU classifies Hydrolyzed Potato Protein as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Hydrolyzed Potato Protein allowed in the EU?
Hydrolyzed Potato Protein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrolyzed Potato Protein do in cosmetics?
Hydrolyzed Potato Protein functions as: Antistatic, hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 100209-45-8.
What is the Margin of Safety for Hydrolyzed Potato Protein?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydrolyzed Potato Protein?
The NOAEL (No Observed Adverse Effect Level) for Hydrolyzed Potato Protein is 50000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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