Poor Cosmetic Ingredient NOAEL Data

Hydroxycyclohexyl Phenyl Ketone

INCI: 1-HYDROXYCYCLOHEXYL PHENYL KETONE

CAS Number
947-19-3
Function
Photoinitiator — initiates UV-curable polymerisation in coatings, inks, adhesives
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not a cosmetic ingredient — no cosmetic-specific CFR listing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Hydroxycyclohexyl Phenyl Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

Industrial photoinitiator not intended for direct skin-contact cosmetics. Presence in a cosmetic product would indicate contamination from UV-cured packaging or coating migration. Known skin/eye irritant. Not approvable in a CPSR. If detected, investigate packaging source.

⚠️
Concern Level: High

Frequently Asked Questions

Is Hydroxycyclohexyl Phenyl Ketone safe in cosmetics?

Industrial photoinitiator not intended for direct skin-contact cosmetics. Presence in a cosmetic product would indicate contamination from UV-cured packaging or coating migration. Known skin/eye irritant. Not approvable in a CPSR. If detected, investigate packaging source. The EU classifies Hydroxycyclohexyl Phenyl Ketone as "permitted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Hydroxycyclohexyl Phenyl Ketone allowed in the EU?

Hydroxycyclohexyl Phenyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxycyclohexyl Phenyl Ketone do in cosmetics?

Hydroxycyclohexyl Phenyl Ketone functions as: Photoinitiator — initiates UV-curable polymerisation in coatings, inks, adhesives. It is classified as a cosmetic ingredient in our database. CAS number: 947-19-3.

What is the Margin of Safety for Hydroxycyclohexyl Phenyl Ketone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hydroxycyclohexyl Phenyl Ketone?

The NOAEL (No Observed Adverse Effect Level) for Hydroxycyclohexyl Phenyl Ketone is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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