Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Sodium Thioglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=180 mg/kg bw/day | dermal | rat | dermal | REACH |
| LOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=360 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | 0.5 other | dermal | code:3484 | dermal | REACH |
Expert Verdict
Strong alkaline pH required for function creates irritation risk; mandatory label warnings ("Contains thioglycolate," "Follow instructions," "Keep away from children"); eye contact hazard; must not be used on broken skin
Regulatory Flags
Frequently Asked Questions
Is Sodium Thioglycolate safe in cosmetics?
Strong alkaline pH required for function creates irritation risk; mandatory label warnings ("Contains thioglycolate," "Follow instructions," "Keep away from children"); eye contact hazard; must not be used on broken skin The EU classifies Sodium Thioglycolate as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Sodium Thioglycolate allowed in the EU?
Sodium Thioglycolate EU regulatory status: restricted. Maximum allowed concentration: 5.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Thioglycolate do in cosmetics?
Sodium Thioglycolate functions as: Depilatory agent, hair waving/straightening, reducing agent. It is classified as a cosmetic ingredient in our database. CAS number: 367-51-1.
What is the Margin of Safety for Sodium Thioglycolate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Thioglycolate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Thioglycolate is >=180 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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