Is HYDROXYDICHLORODIPHENYL ETHER safe in cosmetics?
HYDROXYDICHLORODIPHENYL ETHER has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
HYDROXYDICHLORODIPHENYL ETHER
Also known as: Snoclosan, UNII-814H7B74XK
HYDROXYDICHLORODIPHENYL ETHER (CAS 3380-30-1) is a cosmetic cosmetic ingredient functioning as Antimicrobial. Reported NOAEL =20 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3380-30-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HYDROXYDICHLORODIPHENYL ETHER is classified GHS Danger (H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5-chloro-2-(4-chlorophenoxy)phenol
InChIKey
BYNQFCJOHGOKSS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for HYDROXYDICHLORODIPHENYL ETHER. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =20 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | dermal | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
CorrosiveEnvironmental Hazard
Hazard Class and Category
Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H318 Causes serious eye damage
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 10; M = 10
Inserted via ATP: ATP10
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for HYDROXYDICHLORODIPHENYL ETHER.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HYDROXYDICHLORODIPHENYL ETHER by CAS number or substance name.
Studies
3
Lowest NOAEL
20 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Snoclosan
UNII-814H7B74XK
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SONECLOSAN
ChEMBL ID
CHEMBL1232142
Max Phase
2
Frequently Asked Questions
Is HYDROXYDICHLORODIPHENYL ETHER allowed in the EU?
HYDROXYDICHLORODIPHENYL ETHER EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does HYDROXYDICHLORODIPHENYL ETHER do in cosmetics?
HYDROXYDICHLORODIPHENYL ETHER functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 3380-30-1.
What is the NOAEL for HYDROXYDICHLORODIPHENYL ETHER?
The NOAEL (No Observed Adverse Effect Level) for HYDROXYDICHLORODIPHENYL ETHER is =20 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is HYDROXYDICHLORODIPHENYL ETHER used outside cosmetics?
HYDROXYDICHLORODIPHENYL ETHER also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HYDROXYDICHLORODIPHENYL ETHER have different safety status in cosmetics vs industrial chemicals?
HYDROXYDICHLORODIPHENYL ETHER is classified GHS Danger (H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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