Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Glucose Oxidase. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 21.13 other | oral | rat | oral | REACH |
Expert Verdict
Low-risk enzyme at reported cosmetic concentrations (≤0.025% leave-on); negligible dermal penetration due to high molecular weight (~160 kDa) and no EU Annex restrictions support safe use in cosmetics, with respiratory sensitization risk primarily occupational.
Regulatory Flags
Frequently Asked Questions
Is Glucose Oxidase safe in cosmetics?
Low-risk enzyme at reported cosmetic concentrations (≤0.025% leave-on); negligible dermal penetration due to high molecular weight (~160 kDa) and no EU Annex restrictions support safe use in cosmetics, with respiratory sensitization risk primarily occupational. The EU classifies Glucose Oxidase as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Glucose Oxidase allowed in the EU?
Glucose Oxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucose Oxidase do in cosmetics?
Glucose Oxidase functions as: Light Stabilizer; Antimicrobial (in situ H2O2 generation). It is classified as a cosmetic ingredient in our database. CAS number: 9001-37-0.
What is the Margin of Safety for Glucose Oxidase?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glucose Oxidase?
The NOAEL (No Observed Adverse Effect Level) for Glucose Oxidase is 21.13 other based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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