Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone)

INCI: HYDROXYETHOXYPHENYL BUTANONE

CAS Number
569646-79-3
Function
Preservative; skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.7%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction; widely used in US market as preservative booster

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

SCCS explicitly rejected 2.0% as unsafe; cannot be used as skin conditioning agent at concentrations above the preservative limit of 0.7%; dual-function use must respect preservative cap

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Concern Level: Moderate

Regulatory Flags

preservative eu_cosing_listed

Frequently Asked Questions

Is Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) safe in cosmetics?

SCCS explicitly rejected 2.0% as unsafe; cannot be used as skin conditioning agent at concentrations above the preservative limit of 0.7%; dual-function use must respect preservative cap The EU classifies Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) as "restricted". Safety rating: GOOD.

Is Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) allowed in the EU?

Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) EU regulatory status: restricted. Maximum allowed concentration: 0.7%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) do in cosmetics?

Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone) functions as: Preservative; skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 569646-79-3.

What is the Margin of Safety for Hydroxyethoxyphenyl Butanone (HEPB / Ethylzingerone)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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