Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Hexanediol (1,2-Hexanediol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 700 mg/kg bw/day | dermal | rat | dermal | REACH |
Expert Verdict
Eye irritant — GHS Category 2A (H319); avoid eye-area contact without appropriate formulation pH buffering; otherwise excellent safety profile
Regulatory Flags
Frequently Asked Questions
Is Hexanediol (1,2-Hexanediol) safe in cosmetics?
Eye irritant — GHS Category 2A (H319); avoid eye-area contact without appropriate formulation pH buffering; otherwise excellent safety profile The EU classifies Hexanediol (1,2-Hexanediol) as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is Hexanediol (1,2-Hexanediol) allowed in the EU?
Hexanediol (1,2-Hexanediol) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexanediol (1,2-Hexanediol) do in cosmetics?
Hexanediol (1,2-Hexanediol) functions as: Solvent, humectant, emollient, preservative booster, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6920-22-5.
What is the Margin of Safety for Hexanediol (1,2-Hexanediol)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hexanediol (1,2-Hexanediol)?
The NOAEL (No Observed Adverse Effect Level) for Hexanediol (1,2-Hexanediol) is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check Hexanediol (1,2-Hexanediol) compliance across multiple jurisdictions:
Related Ingredients
Is Hexanediol (1,2-Hexanediol) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexanediol (1,2-Hexanediol) in your formulation.