Is Dipotassium EDTA safe in cosmetics?
Dipotassium EDTA has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Dipotassium EDTA
Also known as: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, potassium salt (1:2), Dipotassium ethylenediaminetetraacetate, EINECS 217-895-0, (Ethylenedinitrilo)tetraacetate dipotassium salt, UNII-3W5S57M958
INCI: DIPOTASSIUM EDTA
Dipotassium EDTA (CAS 2001-94-7) is a cosmetic cosmetic ingredient functioning as Chelating agent; preservative booster. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2001-94-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dipotassium EDTA is classified GHS CMR hazard (H302, H315, H317, H319, H332, H335, H373, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating agent; preservative booster
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
dipotassium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
InChIKey
QLBHNVFOQLIYTH-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR Final Report confirms safety of EDTA and salts (Int J Toxicol 21(Suppl 2):95-142, 2002); FDA permits calcium disodium EDTA as food additive (21 CFR 172.120)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dipotassium EDTA.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dipotassium EDTA.
Regulatory Flags
preservative
Known Synonyms
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, potassium salt (1:2)
Dipotassium ethylenediaminetetraacetate
EINECS 217-895-0
(Ethylenedinitrilo)tetraacetate dipotassium salt
UNII-3W5S57M958
Chemical Function
Chelating agent
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EDETATE DIPOTASSIUM ANHYDROUS
ChEMBL ID
CHEMBL2219741
Max Phase
-1
Frequently Asked Questions
Is Dipotassium EDTA allowed in the EU?
Dipotassium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipotassium EDTA do in cosmetics?
Dipotassium EDTA functions as: Chelating agent; preservative booster. It is classified as a cosmetic ingredient in our database. CAS number: 2001-94-7.
Is Dipotassium EDTA used outside cosmetics?
Dipotassium EDTA also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dipotassium EDTA have different safety status in cosmetics vs industrial chemicals?
Dipotassium EDTA is classified GHS CMR hazard (H302, H315, H317, H319, H332, H335, H373, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dipotassium EDTA compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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